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Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods our scientists could not rule out a concern for genotoxicity and consequently they could not establish a safe level for daily intake of TiO2 as a food additive.
Stability and darkening:
5. Regulatory compliance The MSDS should also include information on regulatory requirements for the safe handling and use of lithopone, including any permits or certifications that may be necessary.